General Information

  • ID:  hor005148
  • Uniprot ID:  P21794
  • Protein name:  Hormone-induced protein 70 kDa
  • Gene name:  NA
  • Organism:  Rattus norvegicus (Rat)
  • Family:  NA
  • Source:  animal
  • Expression:  Most prominent protein induced by estrogen in hypothalamus and most prominent protein induced by LH-RH in pituitary.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  DVLELTDENFESRVSSDTG
  • Length:  19(1-19)
  • Propeptide:  DVLELTDENFESRVSSDTG
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P21794-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    AF-P21794-F1.pdbhor005148_AF2.pdbhor005148_ESM.pdb

Physical Information

Mass: 243441 Formula: C87H137N23O38
Absent amino acids: ACHIKMPQWY Common amino acids: DES
pI: 3.53 Basic residues: 1
Polar residues: 7 Hydrophobic residues: 5
Hydrophobicity: -75.79 Boman Index: -6165
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 71.58
Instability Index: 1959.47 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  2181662
  • Title:  HIP-70: a protein induced by estrogen in the brain and LH-RH in the pituitary.